If Syndicate is anything like De Ting, which I was in for a short period, then anyone can destroy Safehouses. I would suggest a few people making new characters and waiting for a request from The Syndicate. If they even have ranks in their clan then raise in the ranks and wait for our clan to be strong enough, and systematically begin destroying their Safehouses, barricading them for ourselves.
This would probably be less likely to cause a similar retaliation within our clan, and would allow us to deny any responsibility. Yes, become their Ally and milk them for all they are worth, but we need to make sure that we are as safe as possible in destroying them.
To be honest, they aren't very strong. They never clean their ranks, which results in the majority of their 1,000 + members being completely inactive. Still, they are the most widely known and thought to be the most powerful. Bringing them to their knees before the Dragons might would be a considerable victory.